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Published on: July 5, 2017
Antioxidative compounds from Quercus salicina Blume stem
Jung-Il Kim1, Ho-Hyun Kim, Sungun Kim
1College of Pharmacy, Chung-Ang University, 221 Huekseok-Dong Dongjak-Gu, Seoul 156-756, Korea.
Archives of Pharmacal Research
|April 15, 2008
Summary
Five phenolic compounds isolated from Quercus salicina stem extract demonstrated significant antioxidative activity. These compounds showed efficacy in scavenging free radicals and preventing lipid peroxidation in human low-density lipoprotein (LDL).
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Quercus species are known sources of bioactive compounds.
- Phenolic compounds often exhibit antioxidant properties.
- Oxidative stress contributes to various chronic diseases.
Purpose of the Study:
- To isolate and characterize phenolic compounds from Quercus salicina stem.
- To evaluate the antioxidant activities of the isolated compounds.
Main Methods:
- Methanolic extraction of Quercus salicina stem.
- Chromatographic separation techniques for isolation.
- Spectroscopic methods (e.g., NMR, MS) for structural elucidation.
- DPPH assay for radical scavenging activity.
- TBARS assay for anti-lipid peroxidation efficacy on human LDL.
Main Results:
- Five phenolic compounds were isolated and identified: D-threo-guaiacylglycerol 8-O-beta-D-(6'-O-galloyl)glucopyranoside, 9-methoxy-D-threo-guaiacylglycerol 8-O-beta-D-(6'-O-galloyl)glucopyranoside, 6''-O-galloyl salidroside, methyl gallate, and quercetin.
- All five isolated compounds exhibited significant radical scavenging activity.
- All compounds demonstrated anti-lipid peroxidative efficacy on human LDL.
Conclusions:
- Quercus salicina stem is a rich source of potent antioxidative phenolic compounds.
- The identified compounds possess potential therapeutic applications in combating oxidative stress-related conditions.
- Further research into the mechanisms and in vivo efficacy of these compounds is warranted.
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