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Updated: Jul 6, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
[Surgical treatment of the lower extremities varicose veins throughout the ages]
Mariusz Kózka1, Agnieszka Snarska, Tomasz Drygalski
1II Katedra Chirurgii Ogólnej Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie. mkozka@interia.pl
Abstract:
The authors describe a historical review of surgical treatment of varicose veins from antiques to modern methods. Diseases of the veins have been recognized and attempts of their surgical resection have been described since antiquity. Hippocrates wrote about surgical treatment of varicose veins, Celsus and also Galien himself described varicose veins ligatures. The end of 19th century with Trendelenburg and Madelung was a start of modern period of varicose vein surgery. Parallel to surgical the less invasive methods of varicose veins treatment developed and gave a base for modern sclerotherapy.
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