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Related Concept Videos

Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various tubules...
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...

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Articles linked to this work by shared authors, journal, and citation graph.

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Redefining Uric Acid and Cardiovascular Risk: Vascular Gout and Crystal-Driven Vascular Inflammation in Asymptomatic Hyperuricemia.

JACC. Asia·2026
Same author

Soluble uric acid enhances gouty inflammation via activating gene expression related to innate immune responses, M1 macrophage polarization and urate crystal phagocytosis in mouse macrophage-like cells: novel insights into its mechanisms from RNA sequencing.

Hypertension research : official journal of the Japanese Society of Hypertension·2026
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Differential associations of transient hyperuricemia and transient hypouricemia with annual changes in estimated glomerular filtration rate in healthy participants: an observational study.

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Redefining hyperuricemia in chronic kidney disease: a focus on tubulo-glomerular urate handling.

Hypertension research : official journal of the Japanese Society of Hypertension·2025
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Uric acid and hypertension: insights from the joint symposium.

Hypertension research : official journal of the Japanese Society of Hypertension·2025
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Hyperuricemia, A new cardiovascular risk.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2025

Related Experiment Video

Updated: Jul 6, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

[Other antihyperuricemic agents].

Kazuhide Ogino1, Osamu Igawa, Ichiro Hisatome

  • 1Center for Clinical Residency Program, Tottori University Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 16, 2008
PubMed
Summary

Hyperuricemia can lead to serious health issues like cardiovascular disease. Losartan and fenofibrate effectively lower uric acid levels in patients with co-existing hypertension and hyperlipidemia.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Endocrinology

Context:

  • Hyperuricemia is linked to cardiovascular diseases, gout, and kidney damage.
  • Hypertension and hyperlipidemia frequently coexist with hyperuricemia.
  • Managing these associated conditions is crucial for patient outcomes.

Purpose:

  • To evaluate the characteristics and efficacy of losartan and fenofibrate.
  • To assess their utility in managing hyperuricemia in patients with hypertension and hyperlipidemia.

Summary:

  • Losartan, an antihypertensive, and fenofibrate, an antihyperlipidemic, demonstrate uric acid-lowering effects.
  • Both drugs are beneficial for patients with the combined conditions of hyperuricemia, hypertension, and hyperlipidemia.
  • The study details the specific benefits of these agents in this patient population.

Related Experiment Videos

Last Updated: Jul 6, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

Impact:

  • Provides insights into therapeutic options for complex metabolic and cardiovascular conditions.
  • Highlights the dual benefits of losartan and fenofibrate in managing interconnected diseases.
  • Supports evidence-based treatment strategies for hyperuricemia with comorbidities.