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Updated: Jul 6, 2026
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Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum
Published on: January 22, 2019
Emergence of ideal membrane cascades for downstream processing
Edwin N Lightfoot1, Thatcher W Root, Jane L O'Dell
1Department of Chemical and Biological Engineering, University of Wisconsin, Madison, Wisconsin 53706, USA. lightfoot@engr.wisc.edu
Biotechnology Progress
|April 16, 2008
Summary
An algorithm optimizes membrane cascades for separating mixtures, highlighting solvent management
Area of Science:
- Chemical Engineering
- Separation Science
- Bioprocessing
Background:
- Membrane cascades are crucial for separating complex mixtures.
- Current methods face limitations in efficiency and yield for downstream processing.
- Optimizing cascade design is essential for competitive bioseparation.
Purpose of the Study:
- To develop an algorithm for designing ideal membrane cascades.
- To analyze the impact of solvent management on purification and yield.
- To identify needs for improving membrane cascade technology.
Main Methods:
- Algorithm development for membrane cascade simulation.
- Analysis of solvent management strategies.
- Comparative assessment with existing separation techniques.
Main Results:
- Solvent management is critical for achieving high purification and yield.
- The developed algorithm aids in designing efficient membrane cascades.
- Diafiltration enhancement is key for broader application.
Conclusions:
- Optimized membrane cascades offer a competitive alternative to chromatography and simulated moving bed (SMB) operations.
- Efficient diafiltration is necessary for maximizing the potential of membrane cascades.
- This technology is vital for processing larger biomolecules and particles.
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