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Related Experiment Video

Updated: Jul 6, 2026

In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint
07:09

In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint

Published on: March 7, 2014

Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones.

Susannah J Sample1, Mary Behan, Lesley Smith

  • 1Comparative Orthopaedic Research Laboratory, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|April 16, 2008
PubMed
Summary

Bone loading in one bone triggers adaptive responses in other bones, indicating that skeletal adaptation to mechanical stress is neuronally regulated. This neuronal control involves multiple bones and suggests plasticity in bone innervation.

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Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

Area of Science:

  • Bone biology
  • Skeletal physiology
  • Neuroscience

Background:

  • Load-induced bone formation is traditionally viewed as a local process mediated by osteocytes.
  • Emerging hypotheses suggest that functional adaptation of bone may involve neuronal regulation.

Purpose of the Study:

  • To investigate bone formation in multiple bones following the loading of a single bone.
  • To determine if this adaptive bone formation is neuronally regulated.

Main Methods:

  • Mechanical loading of the right ulna in Sprague-Dawley rats at varying peak strain levels.
  • Assessment of bone formation via calcein labeling and measurement of bone neuropeptide concentrations.
  • Temporary neuronal blockade of the brachial plexus using bupivacaine during loading.

Main Results:

  • Loading of one ulna induced adaptive bone formation in contralateral and ipsilateral thoracic limb bones.
  • Neuronal blockade during loading abolished bone formation in the loaded ulna and other affected bones.
  • Skeletal adaptation was more pronounced in distal long bones than proximal ones.
  • Bone neuropeptide concentrations remained altered for 10 days post-loading.

Conclusions:

  • Functional adaptation to mechanical loading in young rats is a neuronally regulated, multi-bone phenomenon.
  • Neuronal pathways play a critical role in mediating skeletal responses to mechanical stimuli.
  • Persistent changes in bone neuropeptides suggest neural plasticity in bone innervation.