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Updated: Jul 6, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements
Akihiro Takiyama1, Hiroshi Nishihara, Ukihide Tateishi
1Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, Kita-Ku, Sapporo, Japan.
Summary
This study reports a rare case of central nervous system lymphomatoid granulomatosis (CNS-LYG) that spread to lymph nodes and bone marrow. The findings suggest CNS-LYG has malignant potential and can disseminate beyond the brain.
Area of Science:
- Neuropathology
- Oncology
- Immunology
Background:
- Lymphomatoid granulomatosis (LYG) is an uncommon lymphoproliferative disorder.
- Central nervous system (CNS) involvement by LYG is rare and characterized by angiocentric lesions.
Observation:
- A 50-year-old male presented with CNS-LYG confirmed by brain biopsy.
- The patient later developed inguinal lymph node swelling, diagnosed as peripheral T-cell lymphoma.
- TCRgamma-gene rearrangement confirmed identical clonal origin in both CNS and lymph node tissues.
Findings:
- The case demonstrates dissemination of CNS-LYG to peripheral lymph nodes.
- Identical TCRgamma-gene rearrangement in CNS and lymph node lesions confirms a single clonal origin.
- This suggests a potential for systemic spread and malignant progression of CNS-LYG.
Implications:
- CNS-LYG may possess greater malignant potential than previously recognized.
- Understanding dissemination patterns is crucial for diagnosing and managing CNS-LYG.
- This case highlights the importance of considering systemic involvement in CNS lymphoproliferative disorders.
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