Complex regional pain syndrome type I in children
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Updated: Jul 6, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
Edward C T H Tan1, Basil Zijlstra, Marlou L Essink
1Department of General Surgery-Traumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. e.tan@chir.umcn.nl
Insights
Complex Regional Pain Syndrome type I (CRPS I) presents differently in children compared to adults. Pediatric CRPS I often involves cooler extremities, more lower limb involvement, and fewer neurological symptoms.
Area of Science:
- Pediatric Pain Medicine
- Neurology
- Rheumatology
Background:
- Complex Regional Pain Syndrome type I (CRPS I) is a debilitating condition following minor trauma.
- While recognized in adults, CRPS I in children is a less understood diagnostic entity.
- Pediatric CRPS I presentation can differ from adults, potentially delaying diagnosis.
Purpose of the Study:
- To investigate and identify key differences in patient characteristics between pediatric and adult CRPS I cases.
- To improve early recognition and management of CRPS I in children.
Main Methods:
- A retrospective chart review was conducted.
- Data from 78 children (age ≤16 years) with CRPS I were analyzed.
- This cohort was compared against a larger group of 951 adult CRPS I patients.
Main Results:
- The pediatric cohort was predominantly female, with a median age of 13 years.
- Children more frequently presented with cooler skin temperature in the affected limb.
- Lower extremity involvement was more common in children, with less pronounced neurological and sympathetic symptoms.
Conclusions:
- CRPS I exhibits distinct clinical features in children compared to adults.
- Understanding these differences is crucial for accurate pediatric diagnosis and treatment.
Background:
Complex Regional Pain Syndrome type I (CRPS I) is a potentially incapacitating syndrome which can occur after a minor injury or operation to a limb. It is a disorder characterized by pain, sensory and motor disturbances. CRPS I is well known in adults, but a relatively new diagnostic entity in children. The clinical presentation of CRPS I in children is, to some extent, different from adults and therefore sometimes not recognized early. The aim of this study was to search for differences in patient characteristics between children and adults with CRPS I.
Methods:
We have performed a retrospective chart review of 78 children (age =16 year) with CRPS I and compared the data with those of 951 adults with CRPS I.
Results:
The child population consisted predominantly of girls and older children (median age 13 years). The child population differed from adults in that the skin temperature of the involved extremity at onset was more often cooler, the lower extremity was involved more frequently and neurological and sympathetic symptoms were less pronounced.
Conclusions:
In several aspects, CRPS I in children has a different presentation than in adults.
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