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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

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Related Experiment Video

Updated: Jul 6, 2026

Homing of Hematopoietic Cells to the Bone Marrow
10:40

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

Communications between bone cells and hematopoietic stem cells.

R L Porter1, L M Calvi

  • 1Endocrine-Metabolism Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, P.O. Box 693, 601 Elmwood Avenue, Rochester, NY 14642, USA.

Archives of Biochemistry and Biophysics
|April 16, 2008
PubMed
Summary
This summary is machine-generated.

Bone marrow

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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

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Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
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Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

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Last Updated: Jul 6, 2026

Homing of Hematopoietic Cells to the Bone Marrow
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Homing of Hematopoietic Cells to the Bone Marrow

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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

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Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

Area of Science:

  • Skeletal Biology
  • Hematopoiesis
  • Cellular Microenvironments

Background:

  • The skeletal system is a dynamic organ system with diverse functions.
  • Mammalian bones are known to host hematopoiesis, the formation of blood cellular components.
  • The bone microenvironment provides regulatory signals to the hematopoietic system.

Purpose of the Study:

  • To review the role of osteoblasts in regulating Hematopoietic Stem Cells (HSCs).
  • To discuss signaling mechanisms and molecules involved in osteoblast-HSC interactions.
  • To explore other cellular components of the HSC niche and clinical implications.

Main Methods:

  • Literature review focusing on osteoblast-HSC interactions.
  • Analysis of signaling pathways and molecular mediators.
  • Discussion of endothelial cells and osteoclasts in the HSC niche.

Main Results:

  • Osteoblasts play a crucial role in regulating primitive Hematopoietic Stem Cells (HSCs).
  • Specific signaling mechanisms and molecules mediate osteoblast modulation of HSC behavior.
  • Endothelial cells and osteoclasts are also key components of the HSC niche.

Conclusions:

  • Emerging understanding of the HSC microenvironment highlights complex cellular interactions.
  • Osteoblasts are critical regulators of HSCs within the bone marrow niche.
  • Further research into the HSC microenvironment has potential clinical applications.