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Published on: July 14, 2023
Parathyroid hormone-like peptide: molecular characterization and biological properties
D Goltzman1, G N Hendy, D Banville
1Departments of Physiology and Medicine, McGill University, Montreal, Canada.
Abstract:
Parathyroid hormone-like peptide (PLP) is a newly discovered novel peptide that interacts with renal and osseous parathyroid hormone (PTH) receptors through its amino-terminal sequence, which is homologous with PTH. Human PLP is the product of a complex single-copy gene, existing in several isoforms which result from alternative exon usage. The peptide was implicated as a causal agent in the hypercalcemia associated with a variety of malignancies, but it may also modulate calcium homeostasis in some normal physiological states and mediate cellular growth or differentiation.
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