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Updated: Jul 5, 2026

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
Published on: February 25, 2022
Growth factors and pituitary tumors
1Neuroendocrine Unit, Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK.
Abstract:
Growth within the anterior pituitary gland is probably controlled by several interacting extracellular messenger molecules, including hypothalamic peptides, target gland hormones, and several growth factors acting in autocrine or paracrine fashion. Adenoma formation may result from abnormal production of such factors or their specific cellular receptors, loss of local inhibitory influences, activation of the intracellular secondary message pathways conveying the mitogenic signal to the nucleus, or deregulation of the nuclear processes controlling mitosis.
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