Related Experiment Video
Updated: Jul 5, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Expression of blood group-related antigens in neoplastic uterine cervix
Cecilia Guzmán-Bistoni1, Bene Pinillos, M Carmen Blanco-Arias
1Instituto Investigación y Ciencia INIPRO, Instituto Canario Investigación Cancer ICIC, Fuerteventura, Canary Islands.
Abstract:
Expression of blood group antigens in normal, displastic and tumoral uterine cervix from 35 hysterectomised women with carcinoma of the cervix was investigated; the results were correlated with patients' ABH phenotype and secretor status. We used an indirect immunoperoxidase technique and a panel of monoclonal antibodies and lectins directed against different antigenic specificities. Anomalous expression of blood group antigens in premalignant lesions from cervix was found. Partial loos of expression of blood group antigens and some lectins in different grades of cervical intraepithelial neoplasia, and a total loss of expression in CIN III and in infiltrating carcinoma of the cervix from secretor patients was revealed. The findings herein described confirm the importance of these antigens as tumour markers and they might be useful for the study of cervical carcinogenesis.
More Related Videos
Related Concept Videos
Uterus and Cervix
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs of...
Histology of the Uterus
The endometrium is the...
Blood Typing
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Uterine Tubes
Rh Blood Group

