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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

Bhanu P Pappu1, Anna Borodovsky, Timothy S Zheng

  • 1Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA.

The Journal of Experimental Medicine
|April 16, 2008
PubMed
Summary

The TL1A-DR3 pathway is crucial for T helper 17 (Th17) cell function in autoimmune diseases. Blocking this pathway reduces Th17 cell activity and disease severity in experimental autoimmune encephalomyelitis (EAE).

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