Accidental Nd:YAG laser-induced choroidal neovascularization
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Updated: Jul 5, 2026

Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss
Published on: April 24, 2020
Howard S Ying1, Robert C A Symons, Kristie L Lin
1The Wilmer Eye Institute at The Johns Hopkins School of Medicine, 600 North Wolfe Street, Maumenee 721, Baltimore, Maryland 21287-9277, USA.
Background:
There are few reports in the literature to describe the natural history of an occupational Nd:YAG laser-induced retinal injury.
Methods:
The chronological response to a Nd:YAG laser-induced injury was studied in a 48-year-old male using the techniques of color fundus photography, fluorescein angiography and optical coherence tomography. When he developed choroidal neovascularization his response to photodynamic therapy with verteporfin was recorded.
Results:
The patient initially developed a macular hole, which spontaneously closed. Three months after the injury a choroidal neovascular membrane developed. This stabilized after the use of photodynamic therapy.
Conclusions:
Surgical closure of Nd:YAG induced macular holes should be delayed to allow spontaneous closure. Photodynamic therapy was successful in treating choroidal neovascularization in this case.
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