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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

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Acitretin for lichen amyloidosus.

James Y J Choi¹, John Sippe, Stephen Lee

¹Department of Dermatology, Concord Repatriation General Hospital, Sydney, New South Wales, Australia. goody_chimes@yahoo.com

The Australasian Journal of Dermatology

|April 17, 2008

Summary

Retinoid therapy, including etretinate and acitretin, effectively manages lichen amyloidosus symptoms like itching and papules. Continuous treatment is crucial, as discontinuing acitretin leads to symptom recurrence.

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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Area of Science:

Dermatology
Pharmacology

Background:

Lichen amyloidosus is a chronic skin condition characterized by itchy, hyperkeratotic papules.
Treatment options for recalcitrant cases remain limited.

Observation:

Two patients with extensive, long-standing lichen amyloidosus were treated with oral retinoids.
One patient received etretinate followed by long-term acitretin; the other received a course of acitretin.

Findings:

Long-term oral acitretin therapy controlled pruritus and flattened papules in a patient with generalized lichen amyloidosus.
Withdrawal of acitretin resulted in symptom flares, which resolved upon reintroduction.
A shorter course of acitretin showed marked improvement, but symptoms recurred after discontinuation.

Implications:

Oral retinoids, particularly acitretin, demonstrate significant efficacy in managing lichen amyloidosus.
Sustained retinoid treatment appears necessary for long-term disease control.
Further research into optimal dosing and duration for lichen amyloidosus is warranted.