Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary recommendations in the prevention and treatment of osteoporosis.

Joint bone spine·2022
Same author

Lipid accumulation and mitochondrial abnormalities are associated with fiber atrophy in the skeletal muscle of rats with collagen-induced arthritis.

Biochimica et biophysica acta. Molecular and cell biology of lipids·2019
Same author

Tackling the question of micronutrients intake as one of the main levers in terms of Inuit food security.

Current opinion in clinical nutrition and metabolic care·2019
Same author

The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis.

Aging·2019
Same author

Impact of Eccentric or Concentric Training on Body Composition and Energy Expenditure.

Medicine and science in sports and exercise·2019
Same author

Towards human exploration of space: The THESEUS review series on nutrition and metabolism research priorities.

NPJ microgravity·2017

Related Experiment Video

Updated: Jul 5, 2026

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay
06:07

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay

Published on: June 7, 2020

Phyto-oestrogens and bone health.

Véronique Coxam1

  • 1Unité de Nutrition Humaine (UMR1019), INRA Theix, 63122 Saint Genès Champanelle, France. coxam@clermont.inra.fr

The Proceedings of the Nutrition Society
|April 17, 2008
PubMed
Summary

Phytoestrogens, plant compounds with weak estrogenic effects, show promise in preventing menopausal bone loss. Further research is needed to confirm their efficacy and safety for postmenopausal women, especially regarding fracture risk.

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Bone Biology

Background:

  • Osteoporosis pathogenesis is linked to oestrogen deficiency, making hormone-replacement therapy a primary prevention method.
  • Hormone-replacement therapy for osteoporosis prophylaxis has limitations.
  • Phytoestrogens, plant-derived compounds with weak oestrogenic activity, are emerging as potential agents for preventing menopausal bone loss.

Purpose of the Study:

  • To evaluate the potential of phytoestrogens in preventing bone loss associated with menopause.
  • To review existing data on phytoestrogens, particularly soy isoflavones, and their impact on bone health.

Main Methods:

  • Review of animal model studies demonstrating improved bone mass with soyabean intake.
  • Analysis of observational studies correlating lower osteoporosis incidence in Eastern populations with high phytoestrogen diets.

More Related Videos

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Related Experiment Videos

Last Updated: Jul 5, 2026

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay
06:07

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay

Published on: June 7, 2020

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

  • Examination of clinical trial data on isoflavones and their effect on bone loss in early postmenopausal women.

    • Main Results:

    • Animal studies provide convincing data for improved bone mass with soyabean consumption.
    • Observational studies suggest a link between phytoestrogen-rich diets and lower osteoporosis rates.
    • Clinical trials indicate that isoflavones may reduce bone loss in early postmenopausal women, but results are not definitive.

    Conclusions:

    • Phytoestrogens, particularly from soy, show potential as an innovative dietary intervention for postmenopausal women.
    • Further large-scale, long-duration clinical investigations are required to establish the definitive effect of phytoestrogens on bone health and fracture risk.
    • The clinical efficacy of soy foods for preventing osteopenia is influenced by intestinal metabolism.