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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

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Systemic contact dermatitis from propylene glycol.

Abigail Lowther¹, Thomas McCormick, Susan Nedorost

¹University Hospitals Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Dermatitis : Contact, Atopic, Occupational, Drug

|April 17, 2008

Summary

This summary is machine-generated.

Contact dermatitis can flare after ingesting allergens like propylene glycol (PG), even after avoiding topical exposure. This highlights the importance of identifying and avoiding dietary sources of PG for persistent eczema.

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Area of Science:

Dermatology
Allergology
Toxicology

Background:

Contact dermatitis is a common skin condition often triggered by topical allergens.
Systemic contact dermatitis (SCD) occurs when ingested substances cause allergic reactions in sensitized individuals.
Propylene glycol (PG) is a widely used ingredient in cosmetics, foods, and medications, posing a potential allergen.

Observation:

A patient developed eczematous plaques after airbag deployment, with positive patch tests to PG and other medicaments.
The dermatitis resolved upon discontinuing topical PG but recurred with ingestion of PG-containing foods.
Persistent eczema despite topical allergen avoidance suggested systemic absorption and reaction.

Findings:

Patch testing revealed sensitivity to propylene glycol (PG), a common ingredient in various products.
Discontinuation of topical PG led to symptom resolution, but dietary PG ingestion triggered recurrent dermatitis.
Persistent positive patch test reactions to PG, even weak ones at day 7, indicated clinical relevance.

Implications:

Systemic contact dermatitis to propylene glycol (PG) should be considered in patients with persistent or recurrent eczema.
Complete avoidance of PG requires careful attention to both topical and dietary sources, including food and medication labels.
Healthcare providers should educate patients on hidden sources of PG and the importance of label verification, especially when dining out.