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Updated: Jul 5, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Cannabis and the developing brain: insights from behavior.

Viviana Trezza1, Vincenzo Cuomo, Louk J M J Vanderschuren

  • 1Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands. vtrezza@umcutrecht.nl

European Journal of Pharmacology
|April 17, 2008
PubMed
Summary
This summary is machine-generated.

Cannabis compounds, like delta-9-tetrahydrocannabinol (THC), impact the developing brain, potentially causing long-term neurobehavioral issues. Research highlights the risks of prenatal and adolescent cannabis exposure on the central nervous system (CNS).

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Published on: February 28, 2025

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Last Updated: Jul 5, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

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Published on: August 18, 2020

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pharmacology

Background:

  • The discovery of delta-9-tetrahydrocannabinol (THC) in 1964 spurred research into cannabis's medical potential.
  • The endocannabinoid system, involved in brain function and development, is crucial for processes like cell proliferation and migration.
  • This system's plasticity during perinatal and adolescent periods means disruptions can have lasting effects.

Purpose of the Study:

  • To review human and animal studies on the neurobehavioral and neurobiological effects of cannabis exposure during development.
  • To understand the health implications of cannabis use by pregnant women and adolescents.
  • To investigate potential adverse effects of cannabinoids on the immature central nervous system (CNS).

Main Methods:

  • Review of human and animal studies.
  • Analysis of neurobiological and behavioral outcomes.
  • Examination of effects from in utero and adolescent cannabis exposure.

Main Results:

  • Cannabis exposure during development can lead to significant neurobehavioral alterations.
  • The endocannabinoid system's role in development makes immature brains vulnerable to cannabinoid compounds.
  • Long-lasting consequences on neurobehavior and potential neuropsychiatric disorders are observed.

Conclusions:

  • Cannabis use during pregnancy and adolescence poses serious health risks due to its impact on the developing brain.
  • Understanding these risks is critical, especially as the endocannabinoid system is a target for treating neuropsychiatric diseases.
  • Further research is warranted to fully elucidate the adverse effects of cannabinoids on the immature CNS.