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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Delayed lupus nephritis.

D-C Varela1, G Quintana, E C Somers

  • 1Cellular Biology and Immunogenetics Unit, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia.

Annals of the Rheumatic Diseases
|April 17, 2008
PubMed
Summary
This summary is machine-generated.

Delayed lupus nephritis (LN) in systemic lupus erythematosus (SLE) patients is common and shares clinical features with early-onset LN. Associated conditions like Sjögren

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Area of Science:

  • Rheumatology
  • Nephrology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with potential multi-organ involvement.
  • Lupus nephritis (LN) is a serious complication of SLE, affecting kidney function.
  • The timing of LN onset relative to SLE diagnosis can influence clinical presentation and outcomes.

Purpose of the Study:

  • To characterize the clinical and immunological profiles of patients experiencing delayed lupus nephritis (LN).
  • To compare patients with delayed LN (>5 years post-SLE onset) against those with early-onset LN (≤5 years post-SLE onset) and patients without nephritis (NLN).

Main Methods:

  • Cross-sectional study comparing three groups: delayed LN (n=48), early-onset LN (n=187), and no LN (n=164).
  • Analysis of clinical manifestations, immunological markers (antibodies, complement levels), and comorbidities.
  • Comparison of renal clinical expression and histopathological patterns between early and delayed LN groups.

Main Results:

  • Delayed LN showed associations with Sjögren's syndrome, lung involvement, and antiphospholipid syndrome compared to early LN.
  • Renal clinical expression and histopathology were similar between delayed and early-onset LN.
  • Higher frequencies of anti-dsDNA, anti-Sm, anti-RNP antibodies, and low complement levels were observed in LN groups versus NLN.
  • Jaccoud's arthropathy was identified as a protective factor against nephritis.

Conclusions:

  • Delayed lupus nephritis is a significant clinical entity in SLE patients.
  • Identifying associated risk factors can improve diagnosis and risk stratification for LN.
  • Understanding delayed LN aids in managing SLE complications and patient care.