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Published on: February 8, 2019
EULAR recommendations for the management of large vessel vasculitis
C Mukhtyar1, L Guillevin, M C Cid
1University of Oxford, Oxford, UK.
Insights
This study presents European League Against Rheumatism (EULAR) recommendations for managing large vessel vasculitis. These evidence-based guidelines aid clinicians in patient assessment, investigation, and treatment.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Large vessel vasculitis (LVV) requires standardized management strategies.
- Current treatment protocols for LVV may lack comprehensive, evidence-based guidelines.
- The European League Against Rheumatism (EULAR) initiated the development of LVV management recommendations.
Framework:
- A modified Delphi technique was employed to identify key management topics for LVV.
- An international expert panel, including rheumatologists, nephrologists, immunologists, and internists, contributed to the process.
- Standardized EULAR operating procedures guided the development of the recommendations.
Implementation:
- Seven distinct recommendations were formulated for the assessment, investigation, and treatment of LVV patients.
- The strength of evidence for some recommendations was limited, necessitating consensus-based opinions.
- Recommendations were derived from a systematic literature search and expert consensus.
Implications:
- The formulated recommendations provide a framework for the clinical management of large vessel vasculitis.
- These guidelines are intended for practical application in daily clinical practice.
- The recommendations aim to improve patient outcomes through standardized care for LVV.
Objectives:
To develop European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis.
Methods:
An expert group (10 rheumatologists, 3 nephrologists, 2 immunolgists, 2 internists representing 8 European countries and the USA, a clinical epidemiologist and a representative from a drug regulatory agency) identified 10 topics for a systematic literature search through a modified Delphi technique. In accordance with standardised EULAR operating procedures, recommendations were derived for the management of large vessel vasculitis. In the absence of evidence, recommendations were formulated on the basis of a consensus opinion.
Results:
Seven recommendations were made relating to the assessment, investigation and treatment of patients with large vessel vasculitis. The strength of recommendations was restricted by the low level of evidence and EULAR standardised operating procedures.
Conclusions:
On the basis of evidence and expert consensus, management recommendations for large vessel vasculitis have been formulated and are commended for use in everyday clinical practice.
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