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Updated: Jul 5, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
A patient with adult erythermalgia: evidence suggesting an autoimmune etiology
Autumn L Jackson1, John A Oates
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Abstract:
We report the case of a woman with a combination of erythermalgia, idiopathic thrombocytopenic purpura, and vitamin B-12 deficiency with positive parietal cell antibodies. The patient was treated with intravenous administration of immunoglobulins together with small doses of prednisone, which resulted in an improvement in her platelet counts, rise in her vitamin B12 levels, and resolution of her painful discolored digits. These findings suggest an underlying autoimmune component to the development of erythermalgia.
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