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Updated: Jul 5, 2026

Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
Published on: April 15, 2021
Coronary artery aneurysms
Michael P Chrissoheris1, Thomas J Donohue, Richard S K Young
1Cardiology Section, Hospital of Saint Raphael, New Haven, Connecticut 06511, USA. mchrissoheris@srhs.org
Insights
Coronary artery aneurysms, often linked to atherosclerosis, stem from diverse causes. Recent research offers new insights into their pathogenesis, imaging, and complications.
Area of Science:
- Cardiology
- Vascular Biology
Background:
- Aneurysmal coronary artery disease is a common clinical finding.
- While atherosclerosis is a frequent cause, other acquired and congenital factors are implicated.
- Understanding coronary aneurysms requires exploring diverse etiologies.
Purpose of the Study:
- To provide an extensive review of recent literature on coronary artery aneurysms.
- To highlight major advances in understanding their pathogenesis and clinical aspects.
- To synthesize current knowledge on diagnosis, management, and complications.
Main Methods:
- Comprehensive literature search of recent studies on coronary aneurysms.
- Analysis of research on pathogenesis, including inflammatory, infectious, and congenital causes.
- Review of advancements in cardiovascular imaging and flow dynamics.
Main Results:
- Recent research has yielded significant findings on the pathogenesis of coronary aneurysms.
- Imaging advancements offer new perspectives on angiographic findings.
- Improved understanding of abnormal flow dynamics and pathophysiology has been achieved.
Conclusions:
- Coronary artery aneurysms have multifactorial etiologies beyond atherosclerosis.
- Advances in research and imaging are enhancing our comprehension of these conditions.
- A critical assessment reveals improved insights into associated complications and pathophysiology.
Abstract:
Aneurysmal coronary artery disease is frequently encountered in clinical cardiology practice. Although more commonly associated with atherosclerosis, a variety of other acquired (eg, inflammatory, infectious, iatrogenic) or congenital causes have been identified. Recent research on the pathogenesis of coronary aneurysms has yielded interesting results. Advances in imaging have also provided new insights as to the nature of angiographic coronary aneurysms. Critical assessment of the abnormal flow dynamics and pathophysiology of aneurysms has been performed and there is an improved understanding of the associated complications. We present an extensive review of the recent literature highlighting the major advances in the field.
Related Concept Videos
Aneurysm I: Introduction
Coronary Artery Disease I: Introduction
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Aneurysm III: Interprofessional Care
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease III: Clinical Manifestations

