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Related Concept Videos

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Cirrhosis II: Pathophysiology

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Related Experiment Video

Updated: Jul 5, 2026

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
07:51

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

Hepatitis C-associated osteosclerosis: a case report.

Kara M Schwartz1, John A Skinner

  • 1Department of Radiology, 200 First Street SW, Rochester, MN 55905, USA.

Skeletal Radiology
|April 17, 2008
PubMed
Summary
This summary is machine-generated.

Hepatitis C-associated osteosclerosis (HCAO) can cause severe bone pain and sclerosis. This case study tracks a patient with HCAO over 15 years, offering insights into its natural history.

Related Experiment Videos

Last Updated: Jul 5, 2026

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
07:51

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

Area of Science:

  • Hepatology
  • Orthopedics
  • Rheumatology

Background:

  • Hepatitis C infection is a global health concern.
  • Hepatitis C-associated osteosclerosis (HCAO) is a rare skeletal complication.
  • The natural history of HCAO remains poorly understood.

Observation:

  • A 38-year-old male presented with severe lower limb pain.
  • Radiographs revealed diffuse skeletal sclerosis and cortical thickening.
  • Iliac crest biopsy confirmed abundant sclerotic bone.

Findings:

  • The patient's symptoms and bone findings were attributed to HCAO.
  • The patient had a 20-year history of hepatitis C infection.
  • Clinical course was monitored over 15 years.

Implications:

  • This case provides valuable insights into the long-term progression of HCAO.
  • Understanding HCAO's natural history can aid in patient management.
  • Further research is needed to elucidate the mechanisms and treatment of HCAO.