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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Flavonols from Bauhinia malabarica
Rawiwun Kaewamatawong1, Mariko Kitajima, Noriyuki Kogure
1Faculty of Pharmaceutical Sciences, Ubon Ratchatani University, Warinchamrap, Ubon Ratchathani Province, 34190, Thailand. rawiwun@yahoo.com
Journal of Natural Medicines
|April 17, 2008
Summary
Bauhinia malabarica Roxb. leaves contain seven flavonols, including kaempferol and quercetin. These compounds are isolated from methanol extracts and have potential medicinal applications.
Area of Science:
- Phytochemistry
- Pharmacognosy
- Traditional Medicine
Background:
- Bauhinia malabarica Roxb. is utilized in Thai traditional medicine for various ailments.
- Traditional uses include wound healing, diuretic, anti-dysentery, and emmenagogue properties.
Purpose of the Study:
- To identify and isolate bioactive compounds from Bauhinia malabarica Roxb. leaves.
- To investigate the chemical constituents responsible for the plant's traditional medicinal uses.
Main Methods:
- Methanol extraction of Bauhinia malabarica Roxb. leaves.
- Isolation and identification of flavonol compounds using chromatographic and spectroscopic techniques.
Main Results:
- Seven flavonol compounds were successfully isolated from the methanol extract.
- Identified compounds include 6,8-di-C-methylkaempferol 3-methyl ether, kaempferol, afzelin, quercetin, isoquercitrin, quercitrin, and hyperoside.
Conclusions:
- The study successfully identified key flavonol constituents in Bauhinia malabarica Roxb. leaves.
- These isolated flavonols may contribute to the plant's observed therapeutic effects in traditional medicine.
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