Bioactive borate glass coatings for titanium alloys
Laxmikanth Peddi1, Richard K Brow, Roger F Brown
1Department of Materials Science & Engineering, Missouri University of Science & Technology, 110 Straumanis Hall, Rolla, MO 65409-0340, USA.
Journal of Materials Science. Materials in Medicine
|April 17, 2008
Summary
New bioactive borate glass coatings for titanium show promise. These coatings form a hydroxyapatite layer in simulated body fluid and exhibit excellent biocompatibility, similar to established Bioglass.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Biomedical Engineering
Background:
- Titanium and its alloys are widely used in biomedical implants due to their excellent mechanical properties and biocompatibility.
- However, direct bone bonding to titanium can be limited, necessitating surface modifications to enhance bioactivity.
- Borate glasses offer potential as bioactive coating materials, but their compatibility with titanium needs thorough investigation.
Purpose of the Study:
- To develop and characterize novel bioactive borate glass coatings for titanium and titanium alloys.
- To evaluate the bioactivity and biocompatibility of these coatings.
- To establish an effective method for applying these coatings to titanium substrates.
Main Methods:
- Synthesis and characterization of Na(2)O-CaO-B(2)O(3) based glasses with SiO(2), Al(2)O(3), and P(2)O(5) additions.
- Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD) for surface layer analysis after immersion in simulated body fluid (SBF).
- In vitro cell culture assays using MC3T3-E1 pre-osteoblastic cells and adhesion strength testing via enameling technique.
Main Results:
- Compositions with thermal expansion matching titanium were identified.
- Formation of a hydroxyapatite surface layer on borate glasses after SBF immersion, confirmed by FTIR and XRD.
- Borate glasses demonstrated in vitro biocompatibility comparable to 45S5 Bioglass((R)).
- Adherent coatings with an adhesive strength of 36 +/- 2 MPa were achieved on Ti6Al4V alloy.
Conclusions:
- The developed borate glasses are bioactive, forming hydroxyapatite in a simulated physiological environment.
- These novel borate glass coatings exhibit good biocompatibility and adhesion to titanium alloys.
- The findings suggest these borate glasses are promising candidates for bioactive coatings on titanium implants.