Related Experiment Video
Updated: Jul 5, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
Published on: May 10, 2017
[Spinal baclofen in trigeminal neuralgia. A case report.]
A Wechsung1, H Müller, H Müller
1Klinik für Anästhesiologie und Intensivmedizin Städtisches Krankenhaus Kemperhof, Koblenzer Straße 115-155, W-5400, Koblenz, Bundesrepublik Deutschland.
Spinal baclofen effectively treats severe trigeminal neuralgia unresponsive to oral medication. This antispastic drug, delivered via spinal injection or infusion, offers a potential therapy for refractory cases.
Area of Science:
- Neurology
- Pharmacology
Context:
- Trigeminal neuralgia is a debilitating neuropathic pain condition.
- Oral baclofen is a common antispastic medication with some efficacy in trigeminal neuralgia.
Purpose:
- To evaluate the efficacy of spinal baclofen administration in a patient with severe trigeminal neuralgia refractory to oral treatments.
Summary:
- Spinal administration of baclofen (100 mug injection) resulted in complete suppression of neuralgic symptoms in a patient unresponsive to oral baclofen.
- Symptoms recurred upon cessation of spinal baclofen but were controlled with continued administration.
- Long-term intrathecal baclofen infusion via an implanted pump proved effective for over a year.
Impact:
- Spinal baclofen represents a promising therapeutic option for severe trigeminal neuralgia resistant to conventional therapies.
- Intrathecal baclofen delivery may offer superior efficacy compared to oral administration for specific patient populations.
Related Concept Videos
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Local Anesthetics: Clinical Application as Spinal Anesthesia
Skeletal Muscle Relaxants: Therapeutic Uses
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...