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Updated: Jul 5, 2026
06:59
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
[New modes of opioid administration.]
H W Striebel1, R Schwagmeier, N Boerger
1Klinik für Anästhesiologie und operative Intensivmedizin Klinikum Steglitz Freie Universität Berlin, Hindenburgdamm 30, 12203, Berlin.
Schmerz (Berlin, Germany)
|September 1, 1993
Summary
New opioid administration methods like oral transmucosal fentanyl citrate (OTFC) and transdermal fentanyl (TTS fentanyl) show promise for managing cancer pain, particularly breakthrough pain. Intranasal opioids also offer rapid relief for acute pain syndromes.
Area of Science:
- Pharmacology
- Pain Management
- Drug Delivery Systems
Context:
- Recent advancements in opioid administration have focused on oral transmucosal, transdermal, peripheral, and nasal routes.
- Traditional methods are being re-evaluated for improved efficacy and patient acceptance.
Purpose:
- To review and compare novel opioid administration methods for pain management.
- To assess the suitability of these methods for different pain types, including cancer pain and postoperative pain.
Summary:
- Oral transmucosal fentanyl citrate (OTFC) is effective for breakthrough cancer pain, with high patient acceptance and rapid onset.
- Transdermal fentanyl (TTS fentanyl) shows potential for cancer pain management, offering stable pharmacokinetics but slower titration for acute pain.
- Peripheral opioid administration shows mixed clinical results, while intranasal opioids provide rapid pain relief suitable for acute pain syndromes.
Impact:
- These novel administration routes offer improved options for managing various pain conditions, especially in cancer patients.
- Understanding the pharmacokinetic profiles and clinical efficacy of these methods is crucial for optimizing pain management strategies.
- High patient acceptance and rapid onset of action are key advantages of several new opioid delivery systems.
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