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Updated: Jul 5, 2026

High-throughput Measurement of Gut Transit Time Using Larval Zebrafish
Published on: October 23, 2018
Measurement of colonic transit using a delayed-release capsule containing radio-opaque markers
Jae Myung Park1, Myung-Gyu Choi, Hwang Choi
1Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Objective:
Colonic transit scintigraphy has several advantages in comparison with radio-opaque marker (ROM) techniques but it is limited to specialized centers. The aim of the study was to validate the ROM technique for measuring colonic transit using delayed-release capsules.
Material And Methods:
Colonic transit is expressed as the sum of the weighted mean marker residence times in the colon (geometric centers). Delayed-release capsules containing radio-opaque markers (DC-ROMs) or scintigraphic methods were compared simultaneously in 10 healthy volunteers. Reproducibility and responsiveness of DC-ROM measurements were evaluated in 10 healthy volunteers at an interval of 2 weeks and after bisacodyl treatment, respectively.
Results:
The transit profiles between the scintigraphic and DC-ROM methods were highly correlated (r = 0.994, p < 0.01). The reproducibility and responsiveness of DC-ROM measurements were good. Colonic transit measured by DC-ROM correlated with the stool form scale (r = 0.66, p < 0.01).
Conclusion:
The DC-ROM test is simple, highly reproducible, responsive, and appropriate for clinical trials and clinical practice.
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