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Fungal infections in hematopoietic stem cell transplant recipients

Kieren A Marr1

  • 1Oregon Health and Sciences University, Portland, Oregon 97239, USA. marrki@ohsu.edu

Medical Mycology
|April 17, 2008
PubMed

Insights

Invasive fungal infections remain a significant risk for hematopoietic stem cell transplant (HSCT) recipients. This review examines changes in fungal infection epidemiology and outcomes in HSCT patients, focusing on candidiasis and mould infections.

Area of Science:

  • Medical Mycology
  • Hematology
  • Transplantation Medicine

Background:

  • Fungal infections are a major cause of transplant-related illness in hematopoietic stem cell transplant (HSCT) recipients.
  • Epidemiology and outcomes of invasive fungal infections have evolved due to changes in transplant procedures and supportive care.

Purpose of the Study:

  • To review invasive fungal infections in HSCT recipients.
  • To focus on host factors and common fungal pathogens, including Candida and moulds.

Main Methods:

  • Literature review of invasive fungal infections in HSCT.
  • Analysis of epidemiological trends and outcomes.
  • Focus on host-specific challenges and common fungal types.

Main Results:

  • Fungal infections continue to be a significant source of morbidity post-HSCT.
  • Changes in transplant practices and care have influenced fungal infection patterns.
  • Candida and mould infections are the most prevalent.

Conclusions:

  • Invasive fungal infections remain a critical concern in HSCT.
  • Understanding evolving epidemiology and host factors is crucial for managing these infections.
  • Targeted strategies for candidiasis and mould infections are essential.

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