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Related Experiment Video

Updated: Jul 5, 2026

Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni

Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni

Published on: January 14, 2018

[Mansonella perstans filariasis].

E R Bregani¹, F Tantardini, A Rovellini

¹Unità Operativa di Medicina d'Urgenza, Fondazione Policlinico-Mangiagalli-Regina Elena, IRCCS, Milano, Italy. rino_bregani@yahoo.it

Parassitologia

|April 17, 2008

Summary

Mansonella perstans infection, often asymptomatic, can cause various symptoms and is difficult to treat. Combination therapy, particularly diethylcarbamazine plus mebendazole, shows higher efficacy than single drugs.

Area of Science:

Medical Parasitology
Infectious Diseases
Tropical Medicine

Background:

Mansonella perstans filariasis is prevalent in Africa and equatorial America.
Historically considered minor, M. perstans infection is now recognized to cause diverse clinical manifestations, including angioedema and joint pain.
Pathological changes may stem from the host's immune response to the parasite.

Purpose of the Study:

To re-evaluate the pathogenicity of Mansonella perstans infection.
To assess the efficacy of various treatment options for M. perstans filariasis.
To determine the optimal therapeutic strategy for this neglected tropical disease.

Main Methods:

Review of recent studies on M. perstans clinical features and immune responses.

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Analysis of treatment outcomes for diethylcarbamazine (DEC), praziquantel, ivermectin, mebendazole, and thiabendazole.

Evaluation of combination therapies, specifically DEC plus mebendazole.

Main Results:

M. perstans infection can lead to symptoms like angioedema, pruritus, fever, and joint pain, often accompanied by eosinophilia.
Standard treatments like DEC are frequently ineffective; praziquantel and ivermectin lack proven rapid efficacy.
Mebendazole demonstrated greater activity than DEC in clearing infection, while thiabendazole showed modest efficacy.
Combination therapy with DEC and mebendazole yielded significantly higher treatment activity compared to monotherapy.

Conclusions:

Mansonella perstans is a more significant pathogen than previously thought, capable of causing substantial clinical illness.
Current monotherapies for M. perstans filariasis are largely inadequate, necessitating alternative treatment strategies.
Combination therapy, particularly mebendazole with DEC, represents a promising approach for effectively treating M. perstans infections.