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[The drug susceptibility of penicillin-resistant Streptococcus pneumoniae]

Sylwia Koiuszko1, Agata Białucha, Eugenia Gospodarek

  • 1Katedra i Zakład Mikrobiologii Collegium Medicum w Bydgoszczy Uniwersytetu Mikołaja Kopemika w Toruniu.

Medycyna Doswiadczalna I Mikrobiologia
|April 18, 2008
PubMed

Insights

Penicillin-resistant Streptococcus pneumoniae (SPPR) strains increased significantly from 2003 to 2006. Most SPPR strains remained susceptible to cefotaxime, indicating a potential treatment option.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Context:

  • The study investigated antimicrobial resistance patterns of Streptococcus pneumoniae.
  • Data was collected from 154 S. pneumoniae strains isolated between 2003 and 2006.
  • The research was conducted at the University Hospital of Dr. A. Jurasza in Bydgoszcz.

Purpose:

  • To evaluate the frequency of isolation of penicillin-resistant Streptococcus pneumoniae (SPPR) strains.
  • To assess the antimicrobial susceptibility of these SPPR strains.
  • To track changes in resistance over a four-year period.

Summary:

  • A significant increase in SPPR strain isolation was observed, rising from 8.2% in 2003 to 32.0% in 2006.
  • SPPR strains were primarily isolated from respiratory tracts, particularly in patients from Neurosurgery, Neurotraumatology, and Rehabilitation clinics.
  • Over 68% of SPPR strains showed intermediate resistance to penicillin, while 73.3% remained susceptible to cefotaxime.
  • Increased resistance to erythromycin, tetracycline, and sulphometoxazole was also noted between 2003 and 2006.

Impact:

  • Highlights the growing challenge of penicillin resistance in Streptococcus pneumoniae.
  • Identifies cefotaxime as a potentially effective antibiotic against resistant strains.
  • Provides crucial data for antimicrobial stewardship and treatment guidelines in the region.
  • Informs public health strategies for managing antibiotic resistance.

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