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Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids
08:15

Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids

Published on: November 15, 2019

[The changes of expression and Fc-gamma-receptor's polypeptide composition of fetal small intestine enterocytes in

D M Masiuk, V S Nedzvets'kyĭ, M I Tsvilikhovs'kyĭ

    Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994)
    |April 18, 2008
    PubMed

    Insights

    Fc-gamma receptors in fetal cattle (Bos primigenius taurus L.) intestine enterocytes were analyzed. Their concentration increased on the apical membrane until the 7th month of fetal development, indicating early immune system maturation.

    Area of Science:

    • Immunology
    • Developmental Biology
    • Gastroenterology

    Context:

    • Fc-gamma receptors (FcγRs) play crucial roles in immune responses.
    • Enterocytes, the primary cells of the intestinal lining, are increasingly recognized for their immune functions.
    • Understanding FcγR expression in fetal development is vital for assessing early immune system maturation in livestock.

    Purpose:

    • To investigate the expression and polypeptide composition of Fc-gamma receptors (FcγRs) in Bos primigenius taurus L. enterocytes during fetal development (3-9 months).
    • To analyze the changes in FcγR concentration on apical and basolateral membranes throughout fetal development.
    • To correlate FcγR presence with the early development of the fetal immune system.

    Summary:

    • Immunoblotting revealed FcγRs composed of 120, 87, 72, and 43 kDa polypeptides in both apical and basolateral enterocyte membranes.
    • FcγR concentration on the apical membrane increased from 3 to 7 months of fetal development, peaking at 7 months.
    • FcγR content was consistently higher on the basolateral membrane compared to the apical membrane.

    Impact:

    • The findings demonstrate active recycling of FcγRs on the plasma membrane of fetal enterocytes.
    • This suggests a significant role for FcγRs in the developing fetal immune system of Bos primigenius taurus L.
    • The study provides foundational data for understanding immune development in cattle fetuses, with potential implications for neonatal health and disease resistance.

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