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Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Jul 5, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Small cell malignant melanoma: an unusual morphologic variant.

I Abbes¹, S Sassi, R Dhouib

¹Department of Cytology and Surgical Pathology, Salah Azaiez Institute, Bab Saadoun, Tunis, Tunisia. imen.abbes@rns.tn

|April 18, 2008

Summary

Small cell melanoma, a rare malignant melanoma variant, presents diagnostic challenges. This case highlights histological difficulties in identifying these small, monomorphic cells, often lacking pigment.

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Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

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Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Patient Derived Cell Culture and Isolation of CD133⁺ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

Area of Science:

Dermatopathology
Oncology

Background:

Small cell melanoma is a rare histological variant of malignant melanoma.
Accurate diagnosis is crucial for appropriate patient management.

Observation:

A case of a brown, ulcerated papule on the left third finger of an 80-year-old woman is presented.
Microscopic examination revealed diffuse sheets of monomorphic small to medium-sized cells within the epidermis.

Findings:

The cells exhibited round to oval, hyperchromatic nuclei with inconspicuous nucleoli.
Melanin pigment was minimal or absent, complicating histological identification.
This morphology posed diagnostic challenges for pathologists.

Implications:

This case underscores the importance of considering rare melanoma variants in differential diagnoses.
Awareness of small cell melanoma's histological features can improve diagnostic accuracy.
Further research into distinguishing features may aid in early detection and treatment.