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Related Experiment Video

Updated: Jul 5, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers
12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

Machine perfusion for 'marginal' liver grafts.

P Dutkowski1, O de Rougemont, P-A Clavien

  • 1Swiss HPB (Hepato-Pancreato-Biliary) Center, Department of Visceral and Transplantation Surgery, University Hospital Zürich, Zurich, Switzerland.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|April 18, 2008
PubMed
Summary

Machine perfusion offers a promising solution for preserving marginal liver grafts, addressing the shortage of donor organs. This technique aims to reduce ischemic damage, improving organ viability for transplantation.

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Can hypothermic oxygenated perfusion (HOPE) rescue futile DCD liver grafts?

HPB : the official journal of the International Hepato Pancreato Biliary Association·2019

Area of Science:

  • Hepatology
  • Transplantation immunology
  • Organ preservation technologies

Background:

  • Critical shortage of deceased donor liver grafts necessitates the use of extended criteria donors.
  • Extended criteria donor grafts exhibit reduced tolerance to ischemia, increasing risks during cold storage.
  • Current cold storage methods are insufficient for preserving marginal quality liver grafts.

Purpose of the Study:

  • To review the role and effectiveness of machine perfusion in preserving marginal liver grafts.
  • To highlight the advantages and disadvantages of current machine perfusion techniques.
  • To elucidate the mechanisms underlying machine perfusion's benefits in liver preservation.

Main Methods:

  • Literature review of studies on machine perfusion for liver preservation.

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Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts
09:29

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

Related Experiment Videos

Last Updated: Jul 5, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers
12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts
09:29

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

  • Analysis of biochemical and functional outcomes of machine perfused marginal liver grafts.
  • Evaluation of the practicability and clinical applicability of different perfusion systems.

    • Main Results:

    • Machine perfusion demonstrates biochemical benefits in limiting ischemic liver damage.
    • Current machine perfusion systems face challenges in clinical practicability.
    • Evidence supports the need for pre-implantation assessment using liver perfusion.

    Conclusions:

    • Machine perfusion is a valuable tool for marginal liver graft preservation, mitigating ischemia-reperfusion injury.
    • Improvements in practicability are needed for widespread clinical adoption of machine liver perfusion.
    • Further research into promising perfusion designs is warranted to optimize outcomes for extended criteria liver donors.