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Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect

Giulia Freer1, Donatella Matteucci, Paola Mazzetti

  • 1Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Via del Brennero 2, I-56127 Pisa, Italy. freer@biomed.unipi.it

Retrovirology
|April 18, 2008
PubMed

Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4+ T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.

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