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Related Concept Videos

Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview01:13

Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview

Attenuated total reflectance (ATR) infrared spectroscopy is a powerful analytical technique used to study the composition of materials. It is widely employed in chemistry, materials science, forensic science, and other fields where sample characterization is required. ATR has several advantages over traditional transmission IR spectroscopy, including the requirement of little to no sample preparation and the ability to analyze a wide range of samples.
The ATR process begins by directing a beam...
Total Internal Reflection Fluorescence Microscopy01:05

Total Internal Reflection Fluorescence Microscopy

Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.

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Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors
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Pulsed terahertz attenuated total reflection spectroscopy.

David A Newnham1, Philip F Taday

  • 1TeraView Limited, Platinum Building, St John's Innovation Park, Cambridge, United Kingdom.

Applied Spectroscopy
|April 18, 2008
PubMed
Summary
This summary is machine-generated.

This study introduces pulsed terahertz attenuated total reflection (ATR) spectroscopy for rapid, non-destructive analysis of solids and liquids. The method requires minimal sample amounts and no preparation, enabling quick sequential measurements.

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Area of Science:

  • Spectroscopy
  • Materials Science
  • Physical Chemistry

Background:

  • Terahertz (THz) spectroscopy offers unique insights into material properties.
  • Attenuated Total Reflection (ATR) enhances sensitivity in spectroscopic measurements.
  • Characterizing diverse materials non-destructively is crucial in many scientific fields.

Purpose of the Study:

  • To present a novel method for pulsed terahertz attenuated total reflection (ATR) spectroscopy.
  • To demonstrate the non-destructive analysis of solid and liquid samples.
  • To highlight the efficiency and minimal sample requirements of the technique.

Main Methods:

  • Utilized a terahertz pulsed spectrometer.
  • Employed silicon ATR modules for spectral acquisition.
  • Recorded spectra in the 0.3 THz to 3.6 THz range (10 cm(-1) to 120 cm(-1)).

Main Results:

  • Successfully obtained pulsed terahertz ATR spectra for solid and liquid materials.
  • Demonstrated non-destructive analysis with minimal sample quantities (approx. 1 mg for solids).
  • Showcased the feasibility of rapid, sequential analyses, significantly reducing overall measurement time.

Conclusions:

  • Pulsed terahertz ATR spectroscopy is an effective technique for rapid, non-destructive material characterization.
  • The method's low sample requirement and lack of preparation make it highly practical.
  • This approach facilitates efficient analysis across various scientific disciplines.