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Updated: Jul 5, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Sublingual immunotherapy and allergic rhinitis.

¹Nova Southeastern University Osteopathic College of Medicine, Fort Lauderdale, FL 33334, USA. lindaswolfcox@msn.com

Current Allergy and Asthma Reports

|April 18, 2008

Summary

Sublingual immunotherapy (SLIT) shows promise for allergic rhinitis treatment, with recent studies identifying an effective dose range. Further research is needed to optimize SLIT dosing and availability in the US.

Area of Science:

Allergy and Immunology
Pharmacology

Background:

Allergic rhinitis is a common condition impacting quality of life.
Sublingual immunotherapy (SLIT) is an alternative to traditional allergy treatments.

Purpose of the Study:

To review the safety and efficacy of sublingual immunotherapy (SLIT) for allergic rhinitis.
To identify an effective dose range for SLIT based on recent evidence.

Main Methods:

Literature review of studies published between 1986 and 2007.
Analysis of recent large-scale patient population studies on SLIT dosing.

Main Results:

Early studies showed a wide range of effective SLIT doses (approx. 6000-fold).
Recent data indicate a clear dose-response relationship, suggesting 15-30 microg of major allergen daily/weekly is effective.

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Local reactions are common; serious adverse events are rare.

Conclusions:

SLIT is a promising treatment for allergic rhinitis.
Optimal dosing and schedules require further investigation.
SLIT is investigational in the US pending FDA approval.