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Updated: Jul 5, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Acute interstitial nephritis of fluindione: about three cases]
Christine Beauchamp1, Ioana Enache, Abraham Haskour
1Département néphrologie-dialyse, centre hospitalier Pierre-Bérégovoy, 58033 Nevers, France. christine.beauchamp@ch-nevers.fr
Abstract:
Acute interstitial nephritis is a frequent cause of acute renal failure, representing about 10% of all biopsied cases. Early recognition of drug-induced acute immunoallergic interstitial nephritis prevents the development of severe chronic renal injury. The list of imputable drugs includes phenindione, a vitamin K antagonist. Fluindione which is also an indanedione derivative is another vitamin K antagonist. We report three biopsy-proved cases of fluindione related acute interstitial nephritis with recovery of renal function after drug withdrawal and prednisone therapy.
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