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[Angina due to anatomical anomalies and to functional changes in the epicardial coronary vessels]
E Barbieri1, G Destro, G Zanotto
1Divisione Clinicizzata Cardiologica, Università degli Studi, Verona.
Insights
Myocardial ischemia with normal coronary arteries can stem from congenital anomalies or functional issues. These conditions, including abnormal coronary artery origins, can lead to sudden death, particularly during physical exertion.
Area of Science:
- Cardiology
- Vascular Biology
- Clinical Medicine
Abstract:
Myocardial ischemia with normal coronary arteries can be due to anatomic or functional reasons. The more severe congenital coronary anomalies in the adulthood are the origin of the left main of the left coronary artery from the right aortic sinus, with a course between the aorta and the pulmonary trunk, and the origin of the left main from the pulmonary trunk. Both these anomalies can cause sudden death, usually associated with physical exertion. The coronary vasomotion of epicardial vessels depends on the interaction of several neurohumoral substances. We report the hemodynamic, angiographic and stress test data of 30 patients affected by chest pain, with myocardial ischemia and normal coronary arteries. In 8 patients the response of epicardial coronary arteries to intracoronary infusion of acetylcholine was evaluated.