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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...

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Related Experiment Video

Updated: Jul 5, 2026

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

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Published on: October 21, 2014

Pseudo-Gaucher cells in multiple myeloma.

Patrick Shenjere¹, Ashok Roy, Brian Eyden

¹Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, United Kingdom. patrick.shenjere@christie.nhs.uk

International Journal of Surgical Pathology

|April 18, 2008

Summary

This summary is machine-generated.

This case report details pseudo-Gaucher cells in multiple myeloma bone marrow, mimicking Gaucher disease. These cells obscured myeloma plasma cells, presenting diagnostic challenges for hematologists.

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Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

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Published on: April 15, 2022

Area of Science:

Hematology
Oncology
Pathology

Background:

Multiple myeloma is a plasma cell malignancy.
Gaucher disease is a lysosomal storage disorder characterized by Gaucher cells.
Histiocytic infiltration can occur in various hematologic conditions.

Observation:

A patient with multiple myeloma presented with bone marrow findings.
The bone marrow showed sheets of histiocytes resembling Gaucher cells.
The patient lacked clinical signs of inherited Gaucher disease.

Findings:

Pseudo-Gaucher cells were identified in the bone marrow aspirate.
These histiocytic cells mimicked Gaucher cells on light microscopy.
The pseudo-Gaucher cells obscured the underlying neoplastic plasma cells.

Implications:

This presentation highlights a potential diagnostic pitfall in hematopathology.
Distinguishing pseudo-Gaucher cells from true Gaucher cells is crucial for accurate diagnosis.
Awareness of this phenomenon aids in the correct diagnosis and management of multiple myeloma.