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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

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Related Experiment Video

Updated: Jul 5, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Calciphylaxis from nonuremic causes: a systematic review.

Sagar U Nigwekar1, Myles Wolf, Richard H Sterns

  • 1Departments of Internal Medicine, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA. sagar.nigwekar@viahealth.org

Clinical Journal of the American Society of Nephrology : CJASN
|April 18, 2008
PubMed
Summary
This summary is machine-generated.

Nonuremic calciphylaxis, a rare condition causing skin lesions, affects patients without kidney disease. This review highlights its diverse causes, high mortality rate, and the need for consideration in affected individuals.

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Published on: November 7, 2017

Area of Science:

  • Nephrology
  • Dermatology
  • Pathology

Background:

  • Calciphylaxis (calcific uremic arteriolopathy) is known in kidney disease patients.
  • Limited data exists on calciphylaxis in nonuremic individuals.

Purpose of the Study:

  • To characterize nonuremic calciphylaxis.
  • Identify etiologies, clinical features, laboratory findings, and prognosis.

Main Methods:

  • Systematic review of case reports and series.
  • Included patients with histopathologic diagnosis of calciphylaxis without kidney disease or renal replacement therapy.

Main Results:

  • 36 cases identified; predominantly white women.
  • Common causes: hyperparathyroidism, malignancy, liver disease, connective tissue disease.
  • 52% mortality; sepsis was the leading cause of death.

Conclusions:

  • Consider nonuremic calciphylaxis in patients with risk factors presenting skin lesions.
  • Pathogenesis may involve heterogeneous mechanisms beyond mineral abnormalities.
  • High mortality underscores the need for effective treatments.