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[Aging and left ventricular diastolic function].

F Rengo1, D Vitale, N Ferrara

  • 1Istituto di Medicina Interna, Cardiologia e Chirurgia Cardiovascolare, II Facoltà di Medicina e Chirurgia, Università degli Studi Federico II, Napoli.

Cardiologia (Rome, Italy)
|December 1, 1991
PubMed
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Physiological aging prolongs cardiac contraction and relaxation times due to reduced calcium uptake. This impacts diastolic function more than systolic function in the aging heart.

Area of Science:

  • Cardiovascular Physiology
  • Gerontology
  • Cardiac Muscle Biology

Context:

  • Physiological aging significantly impacts cardiovascular function.
  • Senescent animal studies reveal prolonged cardiac contraction and relaxation times.
  • Reduced sarcoplasmic reticulum Ca++ uptake is linked to impaired ATPase pump activity.

Purpose:

  • To investigate the effects of aging on cardiac muscle function.
  • To elucidate the mechanisms behind age-related changes in myocardial contractility and relaxation.

Summary:

  • Aging hearts show normal myofilament response to Ca++, peak force, and potentiation.
  • Diminished inotropic response to cardiac glycosides and beta-adrenoceptor stimulation in senescent myocardium.
  • Decreased contractility primarily stems from impaired Ca++ reuptake and relaxation (diastolic phase).

Related Experiment Videos

  • Age-related changes in cardiac structure are linked to increased systolic blood pressure, not significant variations in ventricular size.
  • Myocardial hypertrophy is an adaptive response to increased afterload, not a specific marker of senescence.
  • Alterations in aging cardiac muscle function predominantly involve isovolumic relaxation time and the diastolic phase.

    • Impact:

    • Understanding age-related cardiac dysfunction is crucial for geriatric cardiovascular care.
    • Identifies key mechanisms contributing to diastolic dysfunction in aging hearts.
    • Provides insights into therapeutic targets for age-related cardiovascular diseases.