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Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

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Updated: Jul 5, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Telomeres: the silence is broken.

Claus M Azzalin1, Joachim Lingner

  • 1ETHZ-Eidgenössische Technische Hochschule Zürich, Institute of Biochemistry (IBC), Zürich, Switzerland. claus.azzalin@bc.biol.ethz.ch

Cell Cycle (Georgetown, Tex.)
|April 18, 2008
PubMed
Summary
This summary is machine-generated.

Telomeres, the protective caps on eukaryotic chromosomes, are not silent. New research shows they contain RNA, which is transcribed and stays with telomeric chromatin, suggesting RNA

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Area of Science:

  • Genetics and Molecular Biology
  • Epigenetics
  • Genomic Stability

Background:

  • Telomeres protect linear eukaryotic chromosome ends from DNA damage.
  • They consist of repetitive DNA and associated proteins.
  • Historically, telomeres were considered transcriptionally silent.

Purpose of the Study:

  • To investigate the role of RNA in telomere structure and function.
  • To challenge the notion of telomeres as silent genomic regions.
  • To explore RNA-mediated mechanisms in telomere organization.

Main Methods:

  • Analysis of telomeric transcription in mammalian cells.
  • Characterization of RNA molecules associated with telomeric chromatin.

Main Results:

  • Mammalian telomeres are transcribed into RNA molecules.
  • These RNA molecules remain associated with telomeric chromatin.
  • Evidence suggests RNA is an integral component of telomeres.

Conclusions:

  • Telomeres are not transcriptionally silent genomic regions.
  • RNA plays a role in organizing telomere architecture.
  • RNA-mediated mechanisms are implicated in telomere maintenance and genome stability.