Related Experiment Video
Updated: Jul 5, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Proteinuria in diabetic kidney disease: a mechanistic viewpoint
J A Jefferson1, S J Shankland, R H Pichler
1Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA. jashleyj@u.washington.edu
Abstract:
Proteinuria is the hallmark of diabetic kidney disease (DKD) and is an independent risk factor for both renal disease progression, and cardiovascular disease. Although the characteristic pathological changes in DKD include thickening of the glomerular basement membrane and mesangial expansion, these changes per se do not readily explain how patients develop proteinuria. Recent advances in podocyte and glomerular endothelial cell biology have shifted our focus to also include these cells of the glomerular filtration barrier in the development of proteinuria in DKD. This review describes the pathophysiological mechanisms at a cellular level which explain why patients with DKD develop proteinuria.
Related Concept Videos
Diabetic Nephropathy
Chronic Kidney Disease I: Introduction
Diabetes Insipidus II: Pathophysiology
Nephrotic Syndrome II : Assessment and Medical Management
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Chronic Kidney Disease III: Interprofessional Care