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Blood pressure variability and arterial elasticity in hyperlipidaemic subjects

H M Rafidah1, A Azizi, M N Noriah

  • 1Faculty of Medicine, International Islamic University of Malaysia, Bandar Indera Mahkota, Kuantan 25200, Malaysia. rafidahhanim@gmail.com

Singapore Medical Journal
|April 18, 2008
PubMed

Insights

Hyperlipidaemic individuals exhibit higher blood pressure variability (BPV) compared to those with normal lipid levels. While large arterial compliance showed an inverse correlation with systolic blood pressure, BPV did not correlate with arterial compliance.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Hypertension Research

Background:

  • Assessing myocardial infarction risk solely by low-density lipoprotein or total cholesterol (TC) is debated.
  • The TC to high-density lipoprotein cholesterol (TC:HDL) ratio is a better indicator of coronary artery disease risk.
  • Hyperlipidaemia is defined as a TC:HDL ratio > 5.0.

Purpose of the Study:

  • To investigate the relationship between blood pressure variability (BPV) and arterial compliance in hyperlipidaemic subjects.
  • To compare BPV and arterial compliance in hyperlipidaemic versus normolipidaemic individuals.

Main Methods:

  • Age-, gender-, and weight-matched study design comparing 22 hyperlipidaemic subjects with normolipidaemic controls.
  • 24-hour ambulatory blood pressure monitoring to assess BPV.
  • Measurement of large and small arterial compliances.

Main Results:

  • Hyperlipidaemic subjects demonstrated significantly higher 24-hour systolic, diastolic, and mean arterial BPV.
  • No significant differences in large or small arterial compliances were found between the groups.
  • A significant inverse relationship was observed between systolic blood pressure and large arterial compliance (r=-0.46, p<0.05).
  • No correlation was found between BPV and arterial compliances.

Conclusions:

  • Blood pressure variability is elevated in individuals with hyperlipidaemia.
  • Large arterial compliance is negatively correlated with systolic blood pressure in hyperlipidaemic individuals.
Abstract

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