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[Effects of 3 genosides on bio-thermodynamic expression of splenic lymphocyte in mice]
Jun-Ling Cao1, Zu-Lun Li, Xiao-He Xiao
1Pharmacy Department, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing.
Objective:
To establish a new method for screening active ingredients of Chinese herbs by determining different bio-thermodynamic effects of 3 genosides on splenic lymphocyte of mice.
Methods:
Using a thermal bioactivity monitoring system, the maximum heat output (mHO), average metabolic heat (MH) and constant of decrease rate (DR) of lymphocyte were determined based on the growth metabolic power-time curve, and the outcomes were verified by MIT.
Results:
The mHO and MH increased and the DR decreased after lymphocytes being exposed to the 3 genosides in different concentrations, arranged upon their potency as genoside Rg3 > genoside Rg2 > genoside Rg1 (merely insignificant effect). MTT showed the same results.
Conclusion:
Heat activity monitoring system could precisely display the different bio-thermal dynamic effects of 3 genosides on splenic lymphocyte.
