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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

Updated: Jul 5, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

The clock proteins, aging, and tumorigenesis.

R V Kondratov1, M P Antoch

  • 1BGES Department, Cleveland State University, Cleveland, Ohio 44115, USA.

Cold Spring Harbor Symposia on Quantitative Biology
|April 19, 2008
PubMed
Summary

Mammalian circadian systems regulate physiology and behavior, and their disruption is linked to diseases. New research reveals complex roles for circadian components beyond core clock mechanisms, impacting aging and cancer.

Area of Science:

  • Chronobiology
  • Molecular Biology
  • Physiology

Background:

  • Mammalian physiology and behavior rely on intrinsic timekeeping systems for biological process synchronization.
  • Disruptions in circadian rhythm coordination are implicated in various pathologies.
  • Recent studies reveal a more complex role for the circadian system than previously understood.

Purpose of the Study:

  • To explore the multifaceted roles of circadian system components.
  • To investigate the link between circadian system deregulation and disease development.
  • To identify novel strategies for disease treatment and prevention.

Main Methods:

  • Analysis of studies on mice deficient in individual circadian system components.
  • Review of emerging evidence on the functions of molecular oscillator components.

More Related Videos

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
07:42

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Published on: September 17, 2016

Related Experiment Videos

Last Updated: Jul 5, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
07:42

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Published on: September 17, 2016

  • Examination of the mechanistic links between circadian disruption and pathologies.

    • Main Results:

    • Circadian system components are involved in more than just the core clock mechanism.
    • These components modulate diverse physiological processes including genotoxic stress response, cell cycle regulation, aging, and carcinogenesis.
    • Evidence supports a mechanistic link between circadian system deregulation and disease.

    Conclusions:

    • The circadian system plays a crucial role in maintaining health.
    • Dysregulation of circadian components contributes to various diseases.
    • Understanding these mechanisms offers new avenues for therapeutic interventions and disease prevention.