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MicroRNAs: novel regulators in skin inflammation
E Sonkoly1, M Ståhle, A Pivarcsi
1Molecular Dermatology Research Group, Unit of Dermatology and Venereology, Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Clinical and Experimental Dermatology
|April 19, 2008
Summary
MicroRNAs (miRNAs) are crucial for development. This review explores how specific miRNAs, like miR-203 and miR-146a, are involved in chronic inflammatory skin disorders such as psoriasis and atopic eczema.
Area of Science:
- Molecular Biology
- Dermatology
- Immunology
Background:
- MicroRNAs (miRNAs) are short, non-coding RNAs vital for multicellular organism development and survival.
- miRNAs are increasingly recognized for their roles in the pathogenesis of chronic inflammatory skin diseases, including psoriasis and atopic eczema (AE).
Purpose of the Study:
- To provide an overview of the current understanding of microRNA roles in chronic inflammatory skin disorders.
- To highlight specific miRNAs implicated in the pathogenesis of psoriasis and atopic eczema.
Main Methods:
- Literature review of current research on microRNAs in skin inflammation.
- Analysis of miRNA expression profiles in psoriasis and atopic eczema.
Main Results:
- miR-203, a skin-specific miRNA, is overexpressed in psoriasis.
- miR-146a and miR-125b are upregulated in psoriasis and involved in innate immunity and TNF-alpha pathways.
- miR-125b is also deregulated in atopic eczema.
Conclusions:
- miRNAs play significant roles in the pathogenesis of chronic inflammatory skin disorders.
- miRNAs involved in skin inflammation may serve as potential biomarkers and therapeutic targets for other inflammatory and autoimmune diseases.
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