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MicroRNAs: novel regulators in skin inflammation

E Sonkoly1, M Ståhle, A Pivarcsi

  • 1Molecular Dermatology Research Group, Unit of Dermatology and Venereology, Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.

Clinical and Experimental Dermatology
|April 19, 2008
PubMed

Insights

MicroRNAs (miRNAs) are crucial for development. This review explores how specific miRNAs, like miR-203 and miR-146a, are involved in chronic inflammatory skin disorders such as psoriasis and atopic eczema.

Area of Science:

  • Molecular Biology
  • Dermatology
  • Immunology

Background:

  • MicroRNAs (miRNAs) are short, non-coding RNAs vital for multicellular organism development and survival.
  • miRNAs are increasingly recognized for their roles in the pathogenesis of chronic inflammatory skin diseases, including psoriasis and atopic eczema (AE).

Purpose of the Study:

  • To provide an overview of the current understanding of microRNA roles in chronic inflammatory skin disorders.
  • To highlight specific miRNAs implicated in the pathogenesis of psoriasis and atopic eczema.

Main Methods:

  • Literature review of current research on microRNAs in skin inflammation.
  • Analysis of miRNA expression profiles in psoriasis and atopic eczema.

Main Results:

  • miR-203, a skin-specific miRNA, is overexpressed in psoriasis.
  • miR-146a and miR-125b are upregulated in psoriasis and involved in innate immunity and TNF-alpha pathways.
  • miR-125b is also deregulated in atopic eczema.

Conclusions:

  • miRNAs play significant roles in the pathogenesis of chronic inflammatory skin disorders.
  • miRNAs involved in skin inflammation may serve as potential biomarkers and therapeutic targets for other inflammatory and autoimmune diseases.

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