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PAK'n it in: identification of a selective PAK inhibitor
1Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. bokoch@scripps.edu
Chemistry & Biology
|April 19, 2008
Abstract:
p21-activated kinases are important signaling kinases for which no specific chemical inhibitors are known. In this issue of Chemistry & Biology, Deacon et al. target allosteric transitions undergone during PAK activation to identify a selective inhibitor (Deacon et al., 2008).
