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Oxidative stress and cystic fibrosis-related diabetes: a pilot study in children

Thierry Ntimbane1, Preetha Krishnamoorthy, Céline Huot

  • 1Department of Nutrition, University of Montreal, Montreal, Canada.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|April 19, 2008
PubMed

Insights

Cystic fibrosis (CF) children exhibit increased oxidative stress linked to impaired glucose metabolism. Nutritional recommendations (NR) may help delay cystic fibrosis-related diabetes (CFRD) onset in these patients.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Disorders

Background:

  • Cystic fibrosis (CF) is associated with chronic inflammation and heightened oxidative stress.
  • Understanding the interplay between glucose metabolism and oxidative stress in CF is crucial for patient management.

Purpose of the Study:

  • To investigate the relationship between glucose tolerance and markers of oxidative stress in children with cystic fibrosis.
  • To assess the impact of nutritional interventions on glucose metabolism and oxidative stress in CF patients.

Main Methods:

  • Oral glucose tolerance testing was performed on 31 children (10-18 years old).
  • Blood and urine samples were analyzed for oxidative stress markers (glutathione, HNE-P, DHN-MA).
  • Plasma fatty acid profiles were assessed, and patients with impaired glucose tolerance (IGT) were followed after nutritional recommendations (NR).

Main Results:

  • 42% of CF children presented with impaired glucose tolerance (IGT), and 6% had cystic fibrosis-related diabetes (CFRD).
  • Elevated oxidative stress marker HNE-P correlated with poorer glucose tolerance.
  • Nutritional recommendations (NR) led to normalization of glucose tolerance in 67% of IGT patients, while 22% progressed to CFRD.

Conclusions:

  • CF children demonstrate increased oxidative stress that correlates with worsening glucose metabolism.
  • Nutritional interventions show promise in delaying the progression to CFRD in pediatric CF patients.
Abstract

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