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Oligonucleotides with bis-pyrene adduct in the backbone: syntheses and properties of intramolecular excimer forming
M Kitamura1, A Nimura, K Yamana
1Division of Molecular Engineering, Graduate School of Engineering, Kyoto University, Japan.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
2-(N-bis(2-pyrenylethyl)methyl-amino)ethanol (BPAE) was synthesized and its interaction with DNA was examined to explore the efficiency of intramolecular excimer forming probe. As a result the fluorescence of intramolecular excimer of BPAE disappeared with the addition of poly(dA)-poly(dT). This result suggests an unique type of probe with its introduction to oligonucleotide.